The decision by the ICC's deputy chief prosecutor Nazhat Shameen Khan ends a 13-year legal saga which involved senior Kenyan politicians.
"I have reached this decision after considering the specific facts and circumstances of this situation," she said in a statement.
"Accordingly, the Office will not pursue additional cases into the alleged criminal responsibility of other persons."
In 2010, the Hague-based tribunal started probing post-election fighting in the eastern Africa nation in which prosecutors said 1,300 people died and some 600,000 others were left homeless.
Initially, six suspects faced charges of crimes against humanity, including murder and deportation.
The suspects included former and current Kenyan presidents Uhuru Kenyatta and William Ruto.
But former chief prosecutor Fatou Bensouda withdrew the charges against Kenyatta in 2014 and in 2016 the case against Ruto was stopped too, after judges said the prosecution's evidence was too weak.
The case against all six collapsed due to a lack of evidence.
Bensouda blamed a relentless campaign of victim and witness intimidation for making a trial impossible and prosecutors launched a new probe into witness intimidation and bribery.
Current chief prosecutor Karim Khan was Ruto's defense lawyer at the time and recused himself from the Kenya investigations after taking over the job from Bensouda in 2021.
Kenyan lawyer Paul Gicheru handed himself over to the ICC in late 2020, but the witness bribery case against him was dropped last year after news that he had died.
Two other suspects in the intimidation and bribery case, Philip Bett and Walter Barasa are still at large and face charges before the court.
But the ICC's deputy chief prosecutor Nazhat Shameen Khan on Monday said she was ending further investigations into the post-election violence Kenya.