"Yes, I am indeed a candidate," Kagame, who has ruled over the country with an iron fist for decades, told Jeune Afrique, a French-language news magazine, in an interview published online on Tuesday.
"I am pleased with the confidence that Rwandans have placed in me. I will always serve them, as long as I can," the 65-year-old said.
In March, the Rwandan government decided to synchronize the dates for its parliamentary and presidential elections, which are due to be held in August 2024.
Kagame had previously not made his intentions clear, but presided over controversial constitutional amendments in 2015 that allowed him to run for more terms and stay in power until 2034.
A former rebel chief, Kagame became president in April 2000 but has been regarded as the country's de facto leader since the end of the 1994 genocide.
He was returned to office -with more than 90% of the vote - in elections in 2003, 2010 and 2017.
While Rwanda claims to be one of the most stable countries in Africa, rights groups accuse Kagame of ruling in an atmosphere of fear, stifling dissent and free speech.
'Prisoners'
In 2021, "Hotel Rwanda" hero and outspoken Kagame critic, Paul Rusesabagina, was sentenced to 25 years in jail on terrorism charges. It followed his arrest in 2020 when a plane he believed was bound for Burundi landed instead in Kigali. His family called it a kidnapping.
Rusesabagina was freed from jail in March this year and flown to the United States following a presidential pardon. He released a video message in July, saying that Rwandans were "prisoners in their own country."
The East African nation was ranked 131 out of 180 countries in the 2023 World Press Freedom Index compiled by Reporters Without Borders.
Asked in 2022 if he would seek re-election, Kagame said he would "consider running for another 20 years."
"Elections are about people choosing," he told Paris-based France 24 news channel in an interview.
Kagame was just 36 when his Rwandan Patriotic Front party forced out Hutu extremists blamed for the genocide in which some 800,000 people, mainly Tutsi but also moderate Hutus, were murdered between April and July 1994.