The company said it has started a restructuring process that will impact 3,700 employees — about 17 percent of its work force — after its 2023 profit slumped 71 percent on the previous year.
Coming just months before a general election and affecting a key economic sector, the job cuts are likely to reflect poorly on the government, which is already contending with high unemployment and lackluster growth.
Anglo American Platinum's CEO Craig Miller said the decision was taken as a "last resort" after implementing several other "cost-saving initiatives."
"Given the market outlook and protracted low-price environment due to structural changes in our markets further measures are required to build the resilience that will sustain this business," he said.
The contracts of 620 service providers are also to be reviewed as part of the restructuring process, which involves consultations with labor unions.
Mining employs hundreds of thousands of people in South Africa — the biggest exporter of platinum and a major exporter of gold, diamonds, coal and other raw materials.
The sector accounts for about seven percent of the country's economic output, according to industry figures.
Sitting at more than 32 percent, unemployment is a key political issue ahead of the general election set to take place between May and August.
In power since the advent of democracy in 1994, the ruling African National Congress (ANC) is struggling in the polls, its reputation tainted by accusations of graft and mismanagement.
Polls suggest it could win as little as 40 percent of the vote which would force it to seek a coalition government to stay in power.