One of the two strikes on Tuesday hit the business campus of Mekele University while the other hit Dimitsi Woyane TV station that is run by the regional government, said Kibrom Gebreselassie, chief executive officer at Ayder Referral Hospital. He cited a witness who arrived with a man wounded in the strike.
The second drone knocked the TV station off the air, Dimitsi Woyane said in a statement posted on Facebook. Images shared by the station appeared to show damaged transmission equipment on the building's roof.
Tigrayan regional government spokesperson Getachew Reda said on Twitter that the business campus had been hit by drones.
Ethiopian military spokesperson Colonel Getnet Adane and government spokesperson Legesse Tulu did not respond to requests for comment.
It was third instance of aerial strikes on Mekele since the nearly two-year-old conflict resumed late last month after a five-month ceasefire. Each side has blamed the other for the renewed fighting.
The Tigray People's Liberation Front (TPLF), which governs Tigray, said on Sunday it was ready for a further truce without preconditions and would accept an African Union-led peace process.
Former Nigerian president Olusegun Obasanjo, appointed as the AU's chief mediator, met with the American envoy to the Horn of Africa region, Mike Hammer, on Monday, according to a Twitter post from Djibouti's former ambassador to Ethiopia, Mohamed Idriss Farah, who was also present.
The TPLF dominated national politics for nearly three decades until Prime Minister Abiy Ahmed came to power in 2018.
The TPLF accuses Abiy of centralizing power at the expense of Ethiopia's regions. Abiy denies this and accuses the TPLF of trying to reclaim power, which it denies.