"Canadian P-3 aircraft detected underwater noises in the search area. As a result, ROV (remotely operated vehicle) operations were relocated in an attempt to explore the origin of the noises," the U.S. Coast Guard's First District said on its official Twitter page.
The US Coast Guard announcement is the most encouraging sign yet that those on board may still be alive.
Rescuers estimate that passengers now have less a day of oxygen left, based on the sub's capacity to hold up to 96 hours of emergency air.
U.S. and Canadian coast guard ships and planes are scouring 7,600 square miles (around 20,000 square kilometers) of ocean for the vessel, which was attempting to dive about 400 miles off the coast of Newfoundland, Canada
All communication was lost with the 21-foot (6.5-meter) craft less than two hours during its descent Sunday to see the remains of the British passenger liner, which sits more than two miles (nearly four kilometers) below the surface of the North Atlantic.
The submersible, named Titan, was carrying three fee-paying passengers, including a British billionaire, Hamish Harding, and a Pakistani tycoon Shahzada Dawood, his son Suleman, and French submarine operator Paul-Henri Nargeolet, nicknamed "Mr. Titanic" for his frequent dives at the site. OceanGate Expeditions charges $250,000 for a seat on the sub, which is about the size of an average truck.
The ROV searches had so far not yielded results, but would continue, the military branch said, adding that data from the Canadian aircraft had been shared with U.S. Navy experts to inform future search plans.
Rescue aid has been pouring in from around the world, with a specialized winch system for lifting heavy objects from extreme depths, other equipment and personnel due to join the rescue effort on Tuesday night, according to the U.S. Navy.
The Pentagon said it was deploying a third C-130 aircraft and three C-17s, while France's oceanographic institute announced a deep-sea underwater robot and its experts would arrive in the area on Wednesday.
"This is a very complex search and the unified team is working around the clock to bring all available assets and expertise to bear as quickly as possible," U.S. Coast Guard Captain Jamie Frederick told reporters.
Efforts to find the sub ramped up as a 2018 lawsuit came to light that alleged that OceanGate Expeditions' former director of marine operations was fired after he raised safety concerns about Titan.
David Lochridge cited the company's "experimental and untested design of the Titan" in a court filing.
In an Instagram message posted just before their journey, Harding said a window had opened after days of bad weather and he was proud to be part of the mission.
"Due to the worst winter in Newfoundland in 40 years, this mission is likely to be the first and only manned mission to the Titanic in 2023," he wrote.
Harding, 58, is no stranger to daredevil activities and has three Guinness world records to his name.
A year ago, he became a space tourist through Amazon founder Jeff Bezos's Blue Origin company.
Shahzada and Suleman Dawood hail from one of Pakistan's richest families, which runs Karachi-headquartered conglomerate Engro, with investments in energy, agriculture, petrochemicals and telecommunications.
Mike Reiss, an American television writer who visited the Titanic wreck on the same sub last year, told the BBC the experience was disorientating. The pressure at that depth as measured in atmospheres is 400 times what it is at sea level.
"The compass immediately stopped working and was just spinning around and so we had to flail around blindly at the bottom of the ocean, knowing the Titanic was somewhere there," Reiss said.
He said everyone was aware of the dangers.
"You sign a waiver before you get on and it mentions death three different times on page one."
Without having studied the lost craft itself, Alistair Greig, professor of marine engineering at University College London, suggested two possible scenarios based on images of the Titan published by the press.
He said if it had an electrical or communications problem, it could have surfaced and remained floating, "waiting to be found" -- bearing in mind the vessel can reportedly be unlocked from the outside only.
"Another scenario is the pressure hull was compromised -- a leak," he said in a statement.
"Then the prognosis is not good."
Efforts to find the sub ramped up as a 2018 lawsuit came to light that alleged that OceanGate Expeditions' former director of marine operations was fired after he raised safety concerns about Titan.
David Lochridge cited the company's "experimental and untested design of the Titan" in a court filing.
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