"The Premier League is deeply saddened by the devastating earthquakes in Turkey and Syria, which have killed thousands of people," the English top football flight said in a statement.
"The league will make a £1 million donation to the Disasters Emergency Committee (DEC) Appeal to deliver humanitarian aid directly to those in need."
Premier League players and officials will wear black armbands at matches this weekend.
Italy's Serie A, La Liga in Spain, France's Ligue 1 and Germany's Bundesliga will all hold a minute's silence before matches.
In a statement, Italy's football federation said the silence would be observed across "every league, with games scheduled for the weekend (including matches on Monday)."
"The world of football offers its support to the victims of the earthquake. We can't be indifferent in the face of such a tragedy," said FIGC president Gabriele Gravina.
Monday's 7.8-magnitude quake killed more than 22,000 people in one of the region's worst disasters for a century.
Former Chelsea and Newcastle winger Christian Atsu, who plays for Turkish club Hatayspor, is still missing.