Nigerian football authorities on Friday said Saqid would be replaced by Paul Onuachu.
The West African nation have already lost forward Victor Boniface and midfielder Wilfred Ndidi due to injury.
Despite suffering from a muscle problem, 27-year-old forward Kelechi Iheanacho is expected to arrive in the Ivory Coast on Saturday.
Sadiq’s fitness has been in question due to a knee injury.
The Real Sociedad based player was officially ruled out two days before the Super Eagles opened their tournament against Equatorial Guinea in Abidjan on Sunday.
His 29-year-old replacement, Onuachu, has spent this season on loan at Turkish side Trabzonspor from Southampton, where he has scored nine league goals in 15 starts. He last played for Nigeria in March 2023.
Nigeria will also face hosts Ivory Coast and Guinea-Bissau in Group A.
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